Contact Information Cardiovascular Rsrch Cntr Office 513-558-5636 Email timmens@ucmail.uc.edu Peer Reviewed Publications Bryant, Kathleen G; Swygart, David; Yin, Yuexi; Bauer, Meredith R; Morningstar, Mitchell D; Timme, Nicholas M; Barnett, William H; McGonigle, Colleen E; Engleman, Eric A; Sheets, Patrick L; Lapish, Christopher C 2025. Acute alcohol in prefrontal cortex is characterized by enhanced inhibition that transitions to excitation. iScience, 28 7, 112920N. M. Timme, C. E. Ardinger, S. D. C. Weir, R. Zelaya-Escobar, R. Kruger, C. C. Lapish 2024. Non-consummatory behavior signals predict aversion-resistant alcohol drinking in head-fixed mice Neuropharmacology, 242 , 109762Timme, Nicholas M 2024. Reducing maladaptive behavior in neuropsychiatric disorders using network modification. Frontiers in psychiatry, 15 , 1487275Timme, Nicholas M; Ardinger, Cherish E; Weir, Seth D C; Zelaya-Escobar, Rachel; Kruger, Rachel; Lapish, Christopher C 2024. Non-consummatory behavior signals predict aversion-resistant alcohol drinking in head-fixed mice. Neuropharmacology, 242 , 109762Timme, Nicholas M; Ardinger, Cherish E; Weir, Seth D C; Zelaya-Escobar, Rachel; Kruger, Rachel; Lapish, Christopher C 2023. Non-Consummatory Behavior Signals Predict Aversion-Resistant Alcohol Drinking in Head-Fixed Mice. bioRxiv : the preprint server for biology, , Timme, Nicholas M; Ma, Baofeng; Linsenbardt, David; Cornwell, Ethan; Galbari, Taylor; Lapish, Christopher C 2022. Compulsive alcohol drinking in rodents is associated with altered representations of behavioral control and seeking in dorsal medial prefrontal cortex. Nature communications, 13 1, 3990Sherrill, Samantha P; Timme, Nicholas M; Beggs, John M; Newman, Ehren L 2021. Partial information decomposition reveals that synergistic neural integration is greater downstream of recurrent information flow in organotypic cortical cultures. PLoS computational biology, 17 7, e1009196Sherrill, Samantha P; Timme, Nicholas M; Beggs, John M; Newman, Ehren L 2020. Correlated activity favors synergistic processing in local cortical networks in vitro at synaptically relevant timescales. Network neuroscience (Cambridge, Mass.), 4 3, 678-697Timme, Nicholas M; Linsenbardt, David; Lapish, Christopher C 2020. A Method to Present and Analyze Ensembles of Information Sources. Entropy (Basel, Switzerland), 22 5, Faber, Samantha P; Timme, Nicholas M; Beggs, John M; Newman, Ehren L 2019. Computation is concentrated in rich clubs of local cortical networks. Network neuroscience (Cambridge, Mass.), 3 2, 384-404Linsenbardt, David N; Timme, Nicholas M; Lapish, Christopher C 2019. Encoding of the Intent to Drink Alcohol by the Prefrontal Cortex Is Blunted in Rats with a Family History of Excessive Drinking. eNeuro, 6 4, Janetsian-Fritz, Sarine S; Timme, Nicholas M; Timm, Maureen M; McCane, Aqilah M; Baucum Ii, Anthony J; O'Donnell, Brian F; Lapish, Christopher C 2018. Maternal deprivation induces alterations in cognitive and cortical function in adulthood. Translational psychiatry, 8 1, 71Timme, Nicholas M; Lapish, Christopher 2018. A Tutorial for Information Theory in Neuroscience. eNeuro, 5 3, Marshall, Najja; Timme, Nicholas M; Bennett, Nicholas; Ripp, Monica; Lautzenhiser, Edward; Beggs, John M 2016. Analysis of Power Laws, Shape Collapses, and Neural Complexity: New Techniques and MATLAB Support via the NCC Toolbox. Frontiers in physiology, 7 , 250Nigam, Sunny; Shimono, Masanori; Ito, Shinya; Yeh, Fang-Chin; Timme, Nicholas; Myroshnychenko, Maxym; Lapish, Christopher C; Tosi, Zachary; Hottowy, Pawel; Smith, Wesley C; Masmanidis, Sotiris C; Litke, Alan M; Sporns, Olaf; Beggs, John M 2016. Rich-Club Organization in Effective Connectivity among Cortical Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36 3, 670-84Timme, Nicholas M; Ito, Shinya; Myroshnychenko, Maxym; Nigam, Sunny; Shimono, Masanori; Yeh, Fang-Chin; Hottowy, Pawel; Litke, Alan M; Beggs, John M 2016. High-Degree Neurons Feed Cortical Computations. PLoS computational biology, 12 5, e1004858Timme, Nicholas M; Marshall, Najja J; Bennett, Nicholas; Ripp, Monica; Lautzenhiser, Edward; Beggs, John M 2016. Criticality Maximizes Complexity in Neural Tissue. Frontiers in physiology, 7 , 425Ito, Shinya; Yeh, Fang-Chin; Hiolski, Emma; Rydygier, Przemyslaw; Gunning, Deborah E; Hottowy, Pawel; Timme, Nicholas; Litke, Alan M; Beggs, John M 2014. Large-scale, high-resolution multielectrode-array recording depicts functional network differences of cortical and hippocampal cultures. PloS one, 9 8, e105324Timme, Nicholas; Alford, Wesley; Flecker, Benjamin; Beggs, John M 2014. Synergy, redundancy, and multivariate information measures: an experimentalist's perspective. Journal of computational neuroscience, 36 2, 119-40Timme, Nicholas; Ito, Shinya; Myroshnychenko, Maxym; Yeh, Fang-Chin; Hiolski, Emma; Hottowy, Pawel; Beggs, John M 2014. Multiplex networks of cortical and hippocampal neurons revealed at different timescales. PloS one, 9 12, e115764Beggs, John M; Timme, Nicholas 2012. Being critical of criticality in the brain. Frontiers in physiology, 3 , 163Timme, Nicholas; Morrison, Andrew 2009. The mode shapes of a tennis racket and the effects of vibration dampers on those mode shapes. The Journal of the Acoustical Society of America, 125 6, 3650-56
Peer Reviewed Publications Bryant, Kathleen G; Swygart, David; Yin, Yuexi; Bauer, Meredith R; Morningstar, Mitchell D; Timme, Nicholas M; Barnett, William H; McGonigle, Colleen E; Engleman, Eric A; Sheets, Patrick L; Lapish, Christopher C 2025. Acute alcohol in prefrontal cortex is characterized by enhanced inhibition that transitions to excitation. iScience, 28 7, 112920N. M. Timme, C. E. Ardinger, S. D. C. Weir, R. Zelaya-Escobar, R. Kruger, C. C. Lapish 2024. Non-consummatory behavior signals predict aversion-resistant alcohol drinking in head-fixed mice Neuropharmacology, 242 , 109762Timme, Nicholas M 2024. Reducing maladaptive behavior in neuropsychiatric disorders using network modification. Frontiers in psychiatry, 15 , 1487275Timme, Nicholas M; Ardinger, Cherish E; Weir, Seth D C; Zelaya-Escobar, Rachel; Kruger, Rachel; Lapish, Christopher C 2024. Non-consummatory behavior signals predict aversion-resistant alcohol drinking in head-fixed mice. Neuropharmacology, 242 , 109762Timme, Nicholas M; Ardinger, Cherish E; Weir, Seth D C; Zelaya-Escobar, Rachel; Kruger, Rachel; Lapish, Christopher C 2023. Non-Consummatory Behavior Signals Predict Aversion-Resistant Alcohol Drinking in Head-Fixed Mice. bioRxiv : the preprint server for biology, , Timme, Nicholas M; Ma, Baofeng; Linsenbardt, David; Cornwell, Ethan; Galbari, Taylor; Lapish, Christopher C 2022. Compulsive alcohol drinking in rodents is associated with altered representations of behavioral control and seeking in dorsal medial prefrontal cortex. Nature communications, 13 1, 3990Sherrill, Samantha P; Timme, Nicholas M; Beggs, John M; Newman, Ehren L 2021. Partial information decomposition reveals that synergistic neural integration is greater downstream of recurrent information flow in organotypic cortical cultures. PLoS computational biology, 17 7, e1009196Sherrill, Samantha P; Timme, Nicholas M; Beggs, John M; Newman, Ehren L 2020. Correlated activity favors synergistic processing in local cortical networks in vitro at synaptically relevant timescales. Network neuroscience (Cambridge, Mass.), 4 3, 678-697Timme, Nicholas M; Linsenbardt, David; Lapish, Christopher C 2020. A Method to Present and Analyze Ensembles of Information Sources. Entropy (Basel, Switzerland), 22 5, Faber, Samantha P; Timme, Nicholas M; Beggs, John M; Newman, Ehren L 2019. Computation is concentrated in rich clubs of local cortical networks. Network neuroscience (Cambridge, Mass.), 3 2, 384-404Linsenbardt, David N; Timme, Nicholas M; Lapish, Christopher C 2019. Encoding of the Intent to Drink Alcohol by the Prefrontal Cortex Is Blunted in Rats with a Family History of Excessive Drinking. eNeuro, 6 4, Janetsian-Fritz, Sarine S; Timme, Nicholas M; Timm, Maureen M; McCane, Aqilah M; Baucum Ii, Anthony J; O'Donnell, Brian F; Lapish, Christopher C 2018. Maternal deprivation induces alterations in cognitive and cortical function in adulthood. Translational psychiatry, 8 1, 71Timme, Nicholas M; Lapish, Christopher 2018. A Tutorial for Information Theory in Neuroscience. eNeuro, 5 3, Marshall, Najja; Timme, Nicholas M; Bennett, Nicholas; Ripp, Monica; Lautzenhiser, Edward; Beggs, John M 2016. Analysis of Power Laws, Shape Collapses, and Neural Complexity: New Techniques and MATLAB Support via the NCC Toolbox. Frontiers in physiology, 7 , 250Nigam, Sunny; Shimono, Masanori; Ito, Shinya; Yeh, Fang-Chin; Timme, Nicholas; Myroshnychenko, Maxym; Lapish, Christopher C; Tosi, Zachary; Hottowy, Pawel; Smith, Wesley C; Masmanidis, Sotiris C; Litke, Alan M; Sporns, Olaf; Beggs, John M 2016. Rich-Club Organization in Effective Connectivity among Cortical Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36 3, 670-84Timme, Nicholas M; Ito, Shinya; Myroshnychenko, Maxym; Nigam, Sunny; Shimono, Masanori; Yeh, Fang-Chin; Hottowy, Pawel; Litke, Alan M; Beggs, John M 2016. High-Degree Neurons Feed Cortical Computations. PLoS computational biology, 12 5, e1004858Timme, Nicholas M; Marshall, Najja J; Bennett, Nicholas; Ripp, Monica; Lautzenhiser, Edward; Beggs, John M 2016. Criticality Maximizes Complexity in Neural Tissue. Frontiers in physiology, 7 , 425Ito, Shinya; Yeh, Fang-Chin; Hiolski, Emma; Rydygier, Przemyslaw; Gunning, Deborah E; Hottowy, Pawel; Timme, Nicholas; Litke, Alan M; Beggs, John M 2014. Large-scale, high-resolution multielectrode-array recording depicts functional network differences of cortical and hippocampal cultures. PloS one, 9 8, e105324Timme, Nicholas; Alford, Wesley; Flecker, Benjamin; Beggs, John M 2014. Synergy, redundancy, and multivariate information measures: an experimentalist's perspective. Journal of computational neuroscience, 36 2, 119-40Timme, Nicholas; Ito, Shinya; Myroshnychenko, Maxym; Yeh, Fang-Chin; Hiolski, Emma; Hottowy, Pawel; Beggs, John M 2014. Multiplex networks of cortical and hippocampal neurons revealed at different timescales. PloS one, 9 12, e115764Beggs, John M; Timme, Nicholas 2012. Being critical of criticality in the brain. Frontiers in physiology, 3 , 163Timme, Nicholas; Morrison, Andrew 2009. The mode shapes of a tennis racket and the effects of vibration dampers on those mode shapes. The Journal of the Acoustical Society of America, 125 6, 3650-56
Bryant, Kathleen G; Swygart, David; Yin, Yuexi; Bauer, Meredith R; Morningstar, Mitchell D; Timme, Nicholas M; Barnett, William H; McGonigle, Colleen E; Engleman, Eric A; Sheets, Patrick L; Lapish, Christopher C 2025. Acute alcohol in prefrontal cortex is characterized by enhanced inhibition that transitions to excitation. iScience, 28 7, 112920N. M. Timme, C. E. Ardinger, S. D. C. Weir, R. Zelaya-Escobar, R. Kruger, C. C. Lapish 2024. Non-consummatory behavior signals predict aversion-resistant alcohol drinking in head-fixed mice Neuropharmacology, 242 , 109762Timme, Nicholas M 2024. Reducing maladaptive behavior in neuropsychiatric disorders using network modification. Frontiers in psychiatry, 15 , 1487275Timme, Nicholas M; Ardinger, Cherish E; Weir, Seth D C; Zelaya-Escobar, Rachel; Kruger, Rachel; Lapish, Christopher C 2024. Non-consummatory behavior signals predict aversion-resistant alcohol drinking in head-fixed mice. Neuropharmacology, 242 , 109762Timme, Nicholas M; Ardinger, Cherish E; Weir, Seth D C; Zelaya-Escobar, Rachel; Kruger, Rachel; Lapish, Christopher C 2023. Non-Consummatory Behavior Signals Predict Aversion-Resistant Alcohol Drinking in Head-Fixed Mice. bioRxiv : the preprint server for biology, , Timme, Nicholas M; Ma, Baofeng; Linsenbardt, David; Cornwell, Ethan; Galbari, Taylor; Lapish, Christopher C 2022. Compulsive alcohol drinking in rodents is associated with altered representations of behavioral control and seeking in dorsal medial prefrontal cortex. Nature communications, 13 1, 3990Sherrill, Samantha P; Timme, Nicholas M; Beggs, John M; Newman, Ehren L 2021. Partial information decomposition reveals that synergistic neural integration is greater downstream of recurrent information flow in organotypic cortical cultures. PLoS computational biology, 17 7, e1009196Sherrill, Samantha P; Timme, Nicholas M; Beggs, John M; Newman, Ehren L 2020. Correlated activity favors synergistic processing in local cortical networks in vitro at synaptically relevant timescales. Network neuroscience (Cambridge, Mass.), 4 3, 678-697Timme, Nicholas M; Linsenbardt, David; Lapish, Christopher C 2020. A Method to Present and Analyze Ensembles of Information Sources. Entropy (Basel, Switzerland), 22 5, Faber, Samantha P; Timme, Nicholas M; Beggs, John M; Newman, Ehren L 2019. Computation is concentrated in rich clubs of local cortical networks. Network neuroscience (Cambridge, Mass.), 3 2, 384-404Linsenbardt, David N; Timme, Nicholas M; Lapish, Christopher C 2019. Encoding of the Intent to Drink Alcohol by the Prefrontal Cortex Is Blunted in Rats with a Family History of Excessive Drinking. eNeuro, 6 4, Janetsian-Fritz, Sarine S; Timme, Nicholas M; Timm, Maureen M; McCane, Aqilah M; Baucum Ii, Anthony J; O'Donnell, Brian F; Lapish, Christopher C 2018. Maternal deprivation induces alterations in cognitive and cortical function in adulthood. Translational psychiatry, 8 1, 71Timme, Nicholas M; Lapish, Christopher 2018. A Tutorial for Information Theory in Neuroscience. eNeuro, 5 3, Marshall, Najja; Timme, Nicholas M; Bennett, Nicholas; Ripp, Monica; Lautzenhiser, Edward; Beggs, John M 2016. Analysis of Power Laws, Shape Collapses, and Neural Complexity: New Techniques and MATLAB Support via the NCC Toolbox. Frontiers in physiology, 7 , 250Nigam, Sunny; Shimono, Masanori; Ito, Shinya; Yeh, Fang-Chin; Timme, Nicholas; Myroshnychenko, Maxym; Lapish, Christopher C; Tosi, Zachary; Hottowy, Pawel; Smith, Wesley C; Masmanidis, Sotiris C; Litke, Alan M; Sporns, Olaf; Beggs, John M 2016. Rich-Club Organization in Effective Connectivity among Cortical Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 36 3, 670-84Timme, Nicholas M; Ito, Shinya; Myroshnychenko, Maxym; Nigam, Sunny; Shimono, Masanori; Yeh, Fang-Chin; Hottowy, Pawel; Litke, Alan M; Beggs, John M 2016. High-Degree Neurons Feed Cortical Computations. PLoS computational biology, 12 5, e1004858Timme, Nicholas M; Marshall, Najja J; Bennett, Nicholas; Ripp, Monica; Lautzenhiser, Edward; Beggs, John M 2016. Criticality Maximizes Complexity in Neural Tissue. Frontiers in physiology, 7 , 425Ito, Shinya; Yeh, Fang-Chin; Hiolski, Emma; Rydygier, Przemyslaw; Gunning, Deborah E; Hottowy, Pawel; Timme, Nicholas; Litke, Alan M; Beggs, John M 2014. Large-scale, high-resolution multielectrode-array recording depicts functional network differences of cortical and hippocampal cultures. PloS one, 9 8, e105324Timme, Nicholas; Alford, Wesley; Flecker, Benjamin; Beggs, John M 2014. Synergy, redundancy, and multivariate information measures: an experimentalist's perspective. Journal of computational neuroscience, 36 2, 119-40Timme, Nicholas; Ito, Shinya; Myroshnychenko, Maxym; Yeh, Fang-Chin; Hiolski, Emma; Hottowy, Pawel; Beggs, John M 2014. Multiplex networks of cortical and hippocampal neurons revealed at different timescales. PloS one, 9 12, e115764Beggs, John M; Timme, Nicholas 2012. Being critical of criticality in the brain. Frontiers in physiology, 3 , 163Timme, Nicholas; Morrison, Andrew 2009. The mode shapes of a tennis racket and the effects of vibration dampers on those mode shapes. The Journal of the Acoustical Society of America, 125 6, 3650-56