Education/CredentialsPhD: Ohio State University (Chemistry)BA: Ohio University (Chemistry)BS: Ohio University (Computer Science) Contact Information Medical Sciences Building 3207 Office 513-558-0741 Email garrejn@ucmail.uc.edu Research InterestsMechanisms of mutant HER3 signaling in breast cancer ERBB3, the gene encoding HER3, is mutated in ~2% of breast cancers and other epithelial cancers. This represents approximately 28,000 patients with newly diagnosed cancers each year in the United States. HER3 is an important molecule in estrogen receptor (ER)+ breast cancers, which accounts for about 80% of all breast cancers. HER3 mRNA is highest in ER+ or luminal tumors. About 20% of all breast c... Peer Reviewed Publications Mishra, Rosalin; Patel, Hima; Alanazi, Samar; Kilroy, Mary Kate; Garrett, Joan T 2021. PI3K Inhibitors in Cancer: Clinical Implications and Adverse Effects. International journal of molecular sciences, 22 7, Mishra, Rosalin; Yuan, Long; Patel, Hima; Karve, Aniruddha S; Zhu, Haizhou; White, Aaron; Alanazi, Samar; Desai, Pankaj; Merino, Edward J; Garrett, Joan T 2021. Phosphoinositide 3-Kinase (PI3K) Reactive Oxygen Species (ROS)-Activated Prodrug in Combination with Anthracycline Impairs PI3K Signaling, Increases DNA Damage Response and Reduces Breast Cancer Cell Growth. International journal of molecular sciences, 22 4, Patel, Hima; Mishra, Rosalin; Yacoub, Nour; Alanazi, Samar; Kilroy, Mary Kate; Garrett, Joan T 2021. IGF1R/IR Mediates Resistance to BRAF and MEK Inhibitors in BRAF-Mutant Melanoma. Cancers, 13 22, Patel, Hima; Yacoub, Nour; Mishra, Rosalin; White, Aaron; Long, Yuan; Alanazi, Samar; Garrett, Joan T 2020. Current Advances in the Treatment of BRAF-Mutant Melanoma. Cancers, 12 2, Yuan, Long; Mishra, Rosalin; Patel, Hima; Alanazi, Samar; Wei, Xin; Ma, Zhijun; Garrett, Joan T 2020. BRAF Mutant Melanoma Adjusts to BRAF/MEK Inhibitors via Dependence on Increased Antioxidant SOD2 and Increased Reactive Oxygen Species Levels. Cancers, 12 6, Zhu, Haizhou; Mishra, Rosalin; Yuan, Long; Abdul Salam, Safnas F; Liu, Jing; Gray, George; Sterling, Alyssa D; Wunderlich, Mark; Landero-Figueroa, Julio; Garrett, Joan T; Merino, Edward J 2019. Oxidative Cyclization-Induced Activation of a Phosphoinositide 3-Kinase Inhibitor for Enhanced Selectivity of Cancer Chemotherapeutics. ChemMedChem, 14 22, 1933-1939Mishra, Rosalin; Alanazi, Samar; Yuan, Long; Solomon, Thomas; Thaker, Tarjani M; Jura, Natalia; Garrett, Joan T 2018. Activating HER3 mutations in breast cancer. Oncotarget, 9 45, 27773-27788Mishra, Rosalin; Patel, Hima; Alanazi, Samar; Yuan, Long; Garrett, Joan T 2018. HER3 signaling and targeted therapy in cancer. Oncology reviews, 12 1, 355Yuan, Long; Mishra, Rosalin; Patel, Hima; Abdulsalam, Safnas; Greis, Kenneth D; Kadekaro, Ana Luisa; Merino, Edward J; Garrett, Joan T 2018. Utilization of Reactive Oxygen Species Targeted Therapy to Prolong the Efficacy of BRAF Inhibitors in Melanoma. Journal of Cancer, 9 24, 4665-4676Hanker, Ariella B; Garrett, Joan T; Estrada, Mónica Valeria; Moore, Preston D; Ericsson, Paula González; Koch, James P; Langley, Emma; Singh, Sharat; Kim, Phillip S; Frampton, Garrett M; Sanford, Eric; Owens, Philip; Becker, Jennifer; Groseclose, M Reid; Castellino, Stephen; Joensuu, Heikki; Huober, Jens; Brase, Jan C; Majjaj, Samira; Brohée, Sylvain; Venet, David; Brown, David; Baselga, José; Piccart, Martine; Sotiriou, Christos; Arteaga, Carlos L 2017. HER2-Overexpressing Breast Cancers Amplify FGFR Signaling upon Acquisition of Resistance to Dual Therapeutic Blockade of HER2. Clinical cancer research : an official journal of the American Association for Cancer Research, 23 15, 4323-4334Mishra, Rosalin; Hanker, Ariella B; Garrett, Joan T 2017. Genomic alterations of ERBB receptors in cancer: clinical implications. Oncotarget, 8 69, 114371-114392Schwarz, Luis J; Fox, Emily M; Balko, Justin M; Garrett, Joan T; Kuba, María Gabriela; Estrada, Mónica Valeria; González-Angulo, Ana María; Mills, Gordon B; Red-Brewer, Monica; Mayer, Ingrid A; Abramson, Vandana; Rizzo, Monica; Kelley, Mark C; Meszoely, Ingrid M; Arteaga, Carlos L 2014. LYN-activating mutations mediate antiestrogen resistance in estrogen receptor-positive breast cancer. The Journal of clinical investigation, 124 12, 5490-502Garner, Andrew P; Bialucha, Carl U; Sprague, Elizabeth R; Garrett, Joan T; Sheng, Qing; Li, Sharon; Sineshchekova, Olga; Saxena, Parmita; Sutton, Cammie R; Chen, Dongshu; Chen, Yan; Wang, Huiqin; Liang, Jinsheng; Das, Rita; Mosher, Rebecca; Gu, Jian; Huang, Alan; Haubst, Nicole; Zehetmeier, Carolin; Haberl, Manuela; Elis, Winfried; Kunz, Christian; Heidt, Analeah B; Herlihy, Kara; Murtie, Joshua; Schuller, Alwin; Arteaga, Carlos L; Sellers, William R; Ettenberg, Seth A 2013. An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin. Cancer research, 73 19, 6024-35Garrett, Joan T; Sutton, Cammie R; Kuba, María Gabriela; Cook, Rebecca S; Arteaga, Carlos L 2013. Dual blockade of HER2 in HER2-overexpressing tumor cells does not completely eliminate HER3 function. Clinical cancer research : an official journal of the American Association for Cancer Research, 19 3, 610-9Garrett, Joan T; Sutton, Cammie R; Kurupi, Richard; Bialucha, Carl Uli; Ettenberg, Seth A; Collins, Scott D; Sheng, Qing; Wallweber, Jerry; Defazio-Eli, Lisa; Arteaga, Carlos L 2013. Combination of antibody that inhibits ligand-independent HER3 dimerization and a p110? inhibitor potently blocks PI3K signaling and growth of HER2+ breast cancers. Cancer research, 73 19, 6013-23Cook, Rebecca S; Garrett, Joan T; Sánchez, Violeta; Stanford, Jamie C; Young, Christian; Chakrabarty, Anindita; Rinehart, Cammie; Zhang, Yixian; Wu, Yaming; Greenberger, Lee; Horak, Ivan D; Arteaga, Carlos L 2011. ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis. Cancer research, 71 11, 3941-51Garrett, Joan T; Arteaga, Carlos L 2011. Resistance to HER2-directed antibodies and tyrosine kinase inhibitors: mechanisms and clinical implications. Cancer biology & therapy, 11 9, 793-800Garrett, Joan T; Chakrabarty, Anindita; Arteaga, Carlos L 2011. Will PI3K pathway inhibitors be effective as single agents in patients with cancer? Oncotarget, 2 12, 1314-21Garrett, Joan T; Olivares, María Graciela; Rinehart, Cammie; Granja-Ingram, Nara D; Sánchez, Violeta; Chakrabarty, Anindita; Dave, Bhuvanesh; Cook, Rebecca S; Pao, William; McKinely, Eliot; Manning, H C; Chang, Jenny; Arteaga, Carlos L 2011. Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase. Proceedings of the National Academy of Sciences of the United States of America, 108 12, 5021-6Miller, Todd W; Rexer, Brent N; Garrett, Joan T; Arteaga, Carlos L 2011. Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer. Breast cancer research : BCR, 13 6, 224Kaumaya, Pravin T P; Foy, Kevin Chu; Garrett, Joan; Rawale, Sharad V; Vicari, Daniele; Thurmond, Jennifer M; Lamb, Tammy; Mani, Aruna; Kane, Yahaira; Balint, Catherine R; Chalupa, Donald; Otterson, Gregory A; Shapiro, Charles L; Fowler, Jeffrey M; Grever, Michael R; Bekaii-Saab, Tanios S; Carson, William E 2009. Phase I active immunotherapy with combination of two chimeric, human epidermal growth factor receptor 2, B-cell epitopes fused to a promiscuous T-cell epitope in patients with metastatic and/or recurrent solid tumors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 27 31, 5270-7Allen, Stephanie D; Garrett, Joan T; Rawale, Sharad V; Jones, Audra L; Phillips, Gary; Forni, Guido; Morris, John C; Oshima, Robert G; Kaumaya, Pravin T P 2007. Peptide vaccines of the HER-2/neu dimerization loop are effective in inhibiting mammary tumor growth in vivo. Journal of immunology (Baltimore, Md. : 1950), 179 1, 472-82Garrett, Joan T; Rawale, Sharad; Allen, Stephanie D; Phillips, Gary; Forni, Guido; Morris, John C; Kaumaya, Pravin T P 2007. Novel engineered trastuzumab conformational epitopes demonstrate in vitro and in vivo antitumor properties against HER-2/neu. Journal of immunology (Baltimore, Md. : 1950), 178 11, 7120-31Dakappagari, Naveen K; Lute, Kenneth D; Rawale, Sharad; Steele, Joan T; Allen, Stephanie D; Phillips, Gary; Reilly, R Todd; Kaumaya, Pravin T P 2005. Conformational HER-2/neu B-cell epitope peptide vaccine designed to incorporate two native disulfide bonds enhances tumor cell binding and antitumor activities. The Journal of biological chemistry, 280 1, 54-63
Research InterestsMechanisms of mutant HER3 signaling in breast cancer ERBB3, the gene encoding HER3, is mutated in ~2% of breast cancers and other epithelial cancers. This represents approximately 28,000 patients with newly diagnosed cancers each year in the United States. HER3 is an important molecule in estrogen receptor (ER)+ breast cancers, which accounts for about 80% of all breast cancers. HER3 mRNA is highest in ER+ or luminal tumors. About 20% of all breast c...
Peer Reviewed Publications Mishra, Rosalin; Patel, Hima; Alanazi, Samar; Kilroy, Mary Kate; Garrett, Joan T 2021. PI3K Inhibitors in Cancer: Clinical Implications and Adverse Effects. International journal of molecular sciences, 22 7, Mishra, Rosalin; Yuan, Long; Patel, Hima; Karve, Aniruddha S; Zhu, Haizhou; White, Aaron; Alanazi, Samar; Desai, Pankaj; Merino, Edward J; Garrett, Joan T 2021. Phosphoinositide 3-Kinase (PI3K) Reactive Oxygen Species (ROS)-Activated Prodrug in Combination with Anthracycline Impairs PI3K Signaling, Increases DNA Damage Response and Reduces Breast Cancer Cell Growth. International journal of molecular sciences, 22 4, Patel, Hima; Mishra, Rosalin; Yacoub, Nour; Alanazi, Samar; Kilroy, Mary Kate; Garrett, Joan T 2021. IGF1R/IR Mediates Resistance to BRAF and MEK Inhibitors in BRAF-Mutant Melanoma. Cancers, 13 22, Patel, Hima; Yacoub, Nour; Mishra, Rosalin; White, Aaron; Long, Yuan; Alanazi, Samar; Garrett, Joan T 2020. Current Advances in the Treatment of BRAF-Mutant Melanoma. Cancers, 12 2, Yuan, Long; Mishra, Rosalin; Patel, Hima; Alanazi, Samar; Wei, Xin; Ma, Zhijun; Garrett, Joan T 2020. BRAF Mutant Melanoma Adjusts to BRAF/MEK Inhibitors via Dependence on Increased Antioxidant SOD2 and Increased Reactive Oxygen Species Levels. Cancers, 12 6, Zhu, Haizhou; Mishra, Rosalin; Yuan, Long; Abdul Salam, Safnas F; Liu, Jing; Gray, George; Sterling, Alyssa D; Wunderlich, Mark; Landero-Figueroa, Julio; Garrett, Joan T; Merino, Edward J 2019. Oxidative Cyclization-Induced Activation of a Phosphoinositide 3-Kinase Inhibitor for Enhanced Selectivity of Cancer Chemotherapeutics. ChemMedChem, 14 22, 1933-1939Mishra, Rosalin; Alanazi, Samar; Yuan, Long; Solomon, Thomas; Thaker, Tarjani M; Jura, Natalia; Garrett, Joan T 2018. Activating HER3 mutations in breast cancer. Oncotarget, 9 45, 27773-27788Mishra, Rosalin; Patel, Hima; Alanazi, Samar; Yuan, Long; Garrett, Joan T 2018. HER3 signaling and targeted therapy in cancer. Oncology reviews, 12 1, 355Yuan, Long; Mishra, Rosalin; Patel, Hima; Abdulsalam, Safnas; Greis, Kenneth D; Kadekaro, Ana Luisa; Merino, Edward J; Garrett, Joan T 2018. Utilization of Reactive Oxygen Species Targeted Therapy to Prolong the Efficacy of BRAF Inhibitors in Melanoma. Journal of Cancer, 9 24, 4665-4676Hanker, Ariella B; Garrett, Joan T; Estrada, Mónica Valeria; Moore, Preston D; Ericsson, Paula González; Koch, James P; Langley, Emma; Singh, Sharat; Kim, Phillip S; Frampton, Garrett M; Sanford, Eric; Owens, Philip; Becker, Jennifer; Groseclose, M Reid; Castellino, Stephen; Joensuu, Heikki; Huober, Jens; Brase, Jan C; Majjaj, Samira; Brohée, Sylvain; Venet, David; Brown, David; Baselga, José; Piccart, Martine; Sotiriou, Christos; Arteaga, Carlos L 2017. HER2-Overexpressing Breast Cancers Amplify FGFR Signaling upon Acquisition of Resistance to Dual Therapeutic Blockade of HER2. Clinical cancer research : an official journal of the American Association for Cancer Research, 23 15, 4323-4334Mishra, Rosalin; Hanker, Ariella B; Garrett, Joan T 2017. Genomic alterations of ERBB receptors in cancer: clinical implications. Oncotarget, 8 69, 114371-114392Schwarz, Luis J; Fox, Emily M; Balko, Justin M; Garrett, Joan T; Kuba, María Gabriela; Estrada, Mónica Valeria; González-Angulo, Ana María; Mills, Gordon B; Red-Brewer, Monica; Mayer, Ingrid A; Abramson, Vandana; Rizzo, Monica; Kelley, Mark C; Meszoely, Ingrid M; Arteaga, Carlos L 2014. LYN-activating mutations mediate antiestrogen resistance in estrogen receptor-positive breast cancer. The Journal of clinical investigation, 124 12, 5490-502Garner, Andrew P; Bialucha, Carl U; Sprague, Elizabeth R; Garrett, Joan T; Sheng, Qing; Li, Sharon; Sineshchekova, Olga; Saxena, Parmita; Sutton, Cammie R; Chen, Dongshu; Chen, Yan; Wang, Huiqin; Liang, Jinsheng; Das, Rita; Mosher, Rebecca; Gu, Jian; Huang, Alan; Haubst, Nicole; Zehetmeier, Carolin; Haberl, Manuela; Elis, Winfried; Kunz, Christian; Heidt, Analeah B; Herlihy, Kara; Murtie, Joshua; Schuller, Alwin; Arteaga, Carlos L; Sellers, William R; Ettenberg, Seth A 2013. An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin. Cancer research, 73 19, 6024-35Garrett, Joan T; Sutton, Cammie R; Kuba, María Gabriela; Cook, Rebecca S; Arteaga, Carlos L 2013. Dual blockade of HER2 in HER2-overexpressing tumor cells does not completely eliminate HER3 function. Clinical cancer research : an official journal of the American Association for Cancer Research, 19 3, 610-9Garrett, Joan T; Sutton, Cammie R; Kurupi, Richard; Bialucha, Carl Uli; Ettenberg, Seth A; Collins, Scott D; Sheng, Qing; Wallweber, Jerry; Defazio-Eli, Lisa; Arteaga, Carlos L 2013. Combination of antibody that inhibits ligand-independent HER3 dimerization and a p110? inhibitor potently blocks PI3K signaling and growth of HER2+ breast cancers. Cancer research, 73 19, 6013-23Cook, Rebecca S; Garrett, Joan T; Sánchez, Violeta; Stanford, Jamie C; Young, Christian; Chakrabarty, Anindita; Rinehart, Cammie; Zhang, Yixian; Wu, Yaming; Greenberger, Lee; Horak, Ivan D; Arteaga, Carlos L 2011. ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis. Cancer research, 71 11, 3941-51Garrett, Joan T; Arteaga, Carlos L 2011. Resistance to HER2-directed antibodies and tyrosine kinase inhibitors: mechanisms and clinical implications. Cancer biology & therapy, 11 9, 793-800Garrett, Joan T; Chakrabarty, Anindita; Arteaga, Carlos L 2011. Will PI3K pathway inhibitors be effective as single agents in patients with cancer? Oncotarget, 2 12, 1314-21Garrett, Joan T; Olivares, María Graciela; Rinehart, Cammie; Granja-Ingram, Nara D; Sánchez, Violeta; Chakrabarty, Anindita; Dave, Bhuvanesh; Cook, Rebecca S; Pao, William; McKinely, Eliot; Manning, H C; Chang, Jenny; Arteaga, Carlos L 2011. Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase. Proceedings of the National Academy of Sciences of the United States of America, 108 12, 5021-6Miller, Todd W; Rexer, Brent N; Garrett, Joan T; Arteaga, Carlos L 2011. Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer. Breast cancer research : BCR, 13 6, 224Kaumaya, Pravin T P; Foy, Kevin Chu; Garrett, Joan; Rawale, Sharad V; Vicari, Daniele; Thurmond, Jennifer M; Lamb, Tammy; Mani, Aruna; Kane, Yahaira; Balint, Catherine R; Chalupa, Donald; Otterson, Gregory A; Shapiro, Charles L; Fowler, Jeffrey M; Grever, Michael R; Bekaii-Saab, Tanios S; Carson, William E 2009. Phase I active immunotherapy with combination of two chimeric, human epidermal growth factor receptor 2, B-cell epitopes fused to a promiscuous T-cell epitope in patients with metastatic and/or recurrent solid tumors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 27 31, 5270-7Allen, Stephanie D; Garrett, Joan T; Rawale, Sharad V; Jones, Audra L; Phillips, Gary; Forni, Guido; Morris, John C; Oshima, Robert G; Kaumaya, Pravin T P 2007. Peptide vaccines of the HER-2/neu dimerization loop are effective in inhibiting mammary tumor growth in vivo. Journal of immunology (Baltimore, Md. : 1950), 179 1, 472-82Garrett, Joan T; Rawale, Sharad; Allen, Stephanie D; Phillips, Gary; Forni, Guido; Morris, John C; Kaumaya, Pravin T P 2007. Novel engineered trastuzumab conformational epitopes demonstrate in vitro and in vivo antitumor properties against HER-2/neu. Journal of immunology (Baltimore, Md. : 1950), 178 11, 7120-31Dakappagari, Naveen K; Lute, Kenneth D; Rawale, Sharad; Steele, Joan T; Allen, Stephanie D; Phillips, Gary; Reilly, R Todd; Kaumaya, Pravin T P 2005. Conformational HER-2/neu B-cell epitope peptide vaccine designed to incorporate two native disulfide bonds enhances tumor cell binding and antitumor activities. The Journal of biological chemistry, 280 1, 54-63
Mishra, Rosalin; Patel, Hima; Alanazi, Samar; Kilroy, Mary Kate; Garrett, Joan T 2021. PI3K Inhibitors in Cancer: Clinical Implications and Adverse Effects. International journal of molecular sciences, 22 7, Mishra, Rosalin; Yuan, Long; Patel, Hima; Karve, Aniruddha S; Zhu, Haizhou; White, Aaron; Alanazi, Samar; Desai, Pankaj; Merino, Edward J; Garrett, Joan T 2021. Phosphoinositide 3-Kinase (PI3K) Reactive Oxygen Species (ROS)-Activated Prodrug in Combination with Anthracycline Impairs PI3K Signaling, Increases DNA Damage Response and Reduces Breast Cancer Cell Growth. International journal of molecular sciences, 22 4, Patel, Hima; Mishra, Rosalin; Yacoub, Nour; Alanazi, Samar; Kilroy, Mary Kate; Garrett, Joan T 2021. IGF1R/IR Mediates Resistance to BRAF and MEK Inhibitors in BRAF-Mutant Melanoma. Cancers, 13 22, Patel, Hima; Yacoub, Nour; Mishra, Rosalin; White, Aaron; Long, Yuan; Alanazi, Samar; Garrett, Joan T 2020. Current Advances in the Treatment of BRAF-Mutant Melanoma. Cancers, 12 2, Yuan, Long; Mishra, Rosalin; Patel, Hima; Alanazi, Samar; Wei, Xin; Ma, Zhijun; Garrett, Joan T 2020. BRAF Mutant Melanoma Adjusts to BRAF/MEK Inhibitors via Dependence on Increased Antioxidant SOD2 and Increased Reactive Oxygen Species Levels. Cancers, 12 6, Zhu, Haizhou; Mishra, Rosalin; Yuan, Long; Abdul Salam, Safnas F; Liu, Jing; Gray, George; Sterling, Alyssa D; Wunderlich, Mark; Landero-Figueroa, Julio; Garrett, Joan T; Merino, Edward J 2019. Oxidative Cyclization-Induced Activation of a Phosphoinositide 3-Kinase Inhibitor for Enhanced Selectivity of Cancer Chemotherapeutics. ChemMedChem, 14 22, 1933-1939Mishra, Rosalin; Alanazi, Samar; Yuan, Long; Solomon, Thomas; Thaker, Tarjani M; Jura, Natalia; Garrett, Joan T 2018. Activating HER3 mutations in breast cancer. Oncotarget, 9 45, 27773-27788Mishra, Rosalin; Patel, Hima; Alanazi, Samar; Yuan, Long; Garrett, Joan T 2018. HER3 signaling and targeted therapy in cancer. Oncology reviews, 12 1, 355Yuan, Long; Mishra, Rosalin; Patel, Hima; Abdulsalam, Safnas; Greis, Kenneth D; Kadekaro, Ana Luisa; Merino, Edward J; Garrett, Joan T 2018. Utilization of Reactive Oxygen Species Targeted Therapy to Prolong the Efficacy of BRAF Inhibitors in Melanoma. Journal of Cancer, 9 24, 4665-4676Hanker, Ariella B; Garrett, Joan T; Estrada, Mónica Valeria; Moore, Preston D; Ericsson, Paula González; Koch, James P; Langley, Emma; Singh, Sharat; Kim, Phillip S; Frampton, Garrett M; Sanford, Eric; Owens, Philip; Becker, Jennifer; Groseclose, M Reid; Castellino, Stephen; Joensuu, Heikki; Huober, Jens; Brase, Jan C; Majjaj, Samira; Brohée, Sylvain; Venet, David; Brown, David; Baselga, José; Piccart, Martine; Sotiriou, Christos; Arteaga, Carlos L 2017. HER2-Overexpressing Breast Cancers Amplify FGFR Signaling upon Acquisition of Resistance to Dual Therapeutic Blockade of HER2. Clinical cancer research : an official journal of the American Association for Cancer Research, 23 15, 4323-4334Mishra, Rosalin; Hanker, Ariella B; Garrett, Joan T 2017. Genomic alterations of ERBB receptors in cancer: clinical implications. Oncotarget, 8 69, 114371-114392Schwarz, Luis J; Fox, Emily M; Balko, Justin M; Garrett, Joan T; Kuba, María Gabriela; Estrada, Mónica Valeria; González-Angulo, Ana María; Mills, Gordon B; Red-Brewer, Monica; Mayer, Ingrid A; Abramson, Vandana; Rizzo, Monica; Kelley, Mark C; Meszoely, Ingrid M; Arteaga, Carlos L 2014. LYN-activating mutations mediate antiestrogen resistance in estrogen receptor-positive breast cancer. The Journal of clinical investigation, 124 12, 5490-502Garner, Andrew P; Bialucha, Carl U; Sprague, Elizabeth R; Garrett, Joan T; Sheng, Qing; Li, Sharon; Sineshchekova, Olga; Saxena, Parmita; Sutton, Cammie R; Chen, Dongshu; Chen, Yan; Wang, Huiqin; Liang, Jinsheng; Das, Rita; Mosher, Rebecca; Gu, Jian; Huang, Alan; Haubst, Nicole; Zehetmeier, Carolin; Haberl, Manuela; Elis, Winfried; Kunz, Christian; Heidt, Analeah B; Herlihy, Kara; Murtie, Joshua; Schuller, Alwin; Arteaga, Carlos L; Sellers, William R; Ettenberg, Seth A 2013. An antibody that locks HER3 in the inactive conformation inhibits tumor growth driven by HER2 or neuregulin. Cancer research, 73 19, 6024-35Garrett, Joan T; Sutton, Cammie R; Kuba, María Gabriela; Cook, Rebecca S; Arteaga, Carlos L 2013. Dual blockade of HER2 in HER2-overexpressing tumor cells does not completely eliminate HER3 function. Clinical cancer research : an official journal of the American Association for Cancer Research, 19 3, 610-9Garrett, Joan T; Sutton, Cammie R; Kurupi, Richard; Bialucha, Carl Uli; Ettenberg, Seth A; Collins, Scott D; Sheng, Qing; Wallweber, Jerry; Defazio-Eli, Lisa; Arteaga, Carlos L 2013. Combination of antibody that inhibits ligand-independent HER3 dimerization and a p110? inhibitor potently blocks PI3K signaling and growth of HER2+ breast cancers. Cancer research, 73 19, 6013-23Cook, Rebecca S; Garrett, Joan T; Sánchez, Violeta; Stanford, Jamie C; Young, Christian; Chakrabarty, Anindita; Rinehart, Cammie; Zhang, Yixian; Wu, Yaming; Greenberger, Lee; Horak, Ivan D; Arteaga, Carlos L 2011. ErbB3 ablation impairs PI3K/Akt-dependent mammary tumorigenesis. Cancer research, 71 11, 3941-51Garrett, Joan T; Arteaga, Carlos L 2011. Resistance to HER2-directed antibodies and tyrosine kinase inhibitors: mechanisms and clinical implications. Cancer biology & therapy, 11 9, 793-800Garrett, Joan T; Chakrabarty, Anindita; Arteaga, Carlos L 2011. Will PI3K pathway inhibitors be effective as single agents in patients with cancer? Oncotarget, 2 12, 1314-21Garrett, Joan T; Olivares, María Graciela; Rinehart, Cammie; Granja-Ingram, Nara D; Sánchez, Violeta; Chakrabarty, Anindita; Dave, Bhuvanesh; Cook, Rebecca S; Pao, William; McKinely, Eliot; Manning, H C; Chang, Jenny; Arteaga, Carlos L 2011. Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase. Proceedings of the National Academy of Sciences of the United States of America, 108 12, 5021-6Miller, Todd W; Rexer, Brent N; Garrett, Joan T; Arteaga, Carlos L 2011. Mutations in the phosphatidylinositol 3-kinase pathway: role in tumor progression and therapeutic implications in breast cancer. Breast cancer research : BCR, 13 6, 224Kaumaya, Pravin T P; Foy, Kevin Chu; Garrett, Joan; Rawale, Sharad V; Vicari, Daniele; Thurmond, Jennifer M; Lamb, Tammy; Mani, Aruna; Kane, Yahaira; Balint, Catherine R; Chalupa, Donald; Otterson, Gregory A; Shapiro, Charles L; Fowler, Jeffrey M; Grever, Michael R; Bekaii-Saab, Tanios S; Carson, William E 2009. Phase I active immunotherapy with combination of two chimeric, human epidermal growth factor receptor 2, B-cell epitopes fused to a promiscuous T-cell epitope in patients with metastatic and/or recurrent solid tumors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 27 31, 5270-7Allen, Stephanie D; Garrett, Joan T; Rawale, Sharad V; Jones, Audra L; Phillips, Gary; Forni, Guido; Morris, John C; Oshima, Robert G; Kaumaya, Pravin T P 2007. Peptide vaccines of the HER-2/neu dimerization loop are effective in inhibiting mammary tumor growth in vivo. Journal of immunology (Baltimore, Md. : 1950), 179 1, 472-82Garrett, Joan T; Rawale, Sharad; Allen, Stephanie D; Phillips, Gary; Forni, Guido; Morris, John C; Kaumaya, Pravin T P 2007. Novel engineered trastuzumab conformational epitopes demonstrate in vitro and in vivo antitumor properties against HER-2/neu. Journal of immunology (Baltimore, Md. : 1950), 178 11, 7120-31Dakappagari, Naveen K; Lute, Kenneth D; Rawale, Sharad; Steele, Joan T; Allen, Stephanie D; Phillips, Gary; Reilly, R Todd; Kaumaya, Pravin T P 2005. Conformational HER-2/neu B-cell epitope peptide vaccine designed to incorporate two native disulfide bonds enhances tumor cell binding and antitumor activities. The Journal of biological chemistry, 280 1, 54-63